{"id":7322,"date":"2024-03-04T09:28:58","date_gmt":"2024-03-04T02:28:58","guid":{"rendered":"https:\/\/apanano.com\/vi\/?p=7322"},"modified":"2024-03-04T09:28:58","modified_gmt":"2024-03-04T02:28:58","slug":"cac-chuc-nang-sinh-ly-cua-methionine-o-gia-cam","status":"publish","type":"post","link":"https:\/\/apanano.vn\/vi\/news\/cac-chuc-nang-sinh-ly-cua-methionine-o-gia-cam\/","title":{"rendered":"C\u00e1c ch\u1ee9c n\u0103ng sinh l\u00fd c\u1ee7a methionine \u1edf gia c\u1ea7m"},"content":{"rendered":"

Hi\u1ec3u bi\u1ebft v\u1ec1 l\u1ee3i \u00edch c\u1ee7a c\u00e1c axit amin \u0111\u00e3 c\u00f3 nhi\u1ec1u thay \u0111\u1ed5i trong th\u1eddi gian v\u1eeba qua v\u00ec ng\u00e0nh c\u00f4ng ngh\u1ec7 sinh h\u00f3a ti\u1ebfp t\u1ee5c ph\u00e1t tri\u1ec3n trong ch\u0103n nu\u00f4i \u0111\u1ed9ng v\u1eadt v\u00e0 dinh d\u01b0\u1ee1ng cho con ng\u01b0\u1eddi. \u1ede \u0111\u00e2y, ng\u01b0\u1eddi ta \u0111\u00e3 \u0111\u00e1nh gi\u00e1 c\u00e1c ch\u1ee9c n\u0103ng sinh l\u00fd c\u1ee7a methionine v\u00e0 t\u00ednh hi\u1ec7u qu\u1ea3 c\u1ee7a n\u00f3 khi s\u1eed d\u1ee5ng c\u00e1c ngu\u1ed3n methionine kh\u00e1c nhau.<\/strong><\/p>\n

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Tr\u01b0\u1edbc \u0111\u00e2y, ng\u01b0\u1eddi ta \u0111\u00e3 \u0111\u00e1nh gi\u00e1 \u0111\u01b0\u1ee3c ch\u1ee9c n\u0103ng c\u1ee7a c\u00e1c axit amin ch\u00ednh l\u00e0 gi\u00fap c\u1ea5u tr\u00fac n\u00ean protein. Tuy nhi\u00ean, do nhi\u1ec1u l\u0129nh v\u1ef1c trong ng\u00e0nh c\u00f4ng ngh\u1ec7 sinh h\u1ecdc \u0111\u00e3 ph\u00e1t tri\u1ec3n ch\u1eb3ng h\u1ea1n nh\u01b0 nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o, ng\u01b0\u1eddi ta \u0111\u00e3 ph\u00e1t hi\u1ec7n ra c\u00e1c ch\u1ee9c n\u0103ng sinh l\u00fd c\u1ee7a axit amin v\u00e0 \u0111i\u1ec1u n\u00e0y c\u1ea7n \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc trong vi\u1ec7c x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c th\u1ee9c \u0103n \u0111\u1ec3 t\u1ed1i \u0111a h\u00f3a s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a \u0111\u1ed9ng v\u1eadt.<\/p>\n

V\u00ec l\u01b0\u1ee3ng methionine c\u00f3 h\u1ea1n trong ngu\u1ed3n protein th\u1ef1c v\u1eadt trong khi \u0111\u00f3 gia c\u1ea7m c\u00f3 nhu c\u1ea7u methionine cao \u0111\u1ec3 ph\u00e1t tri\u1ec3n l\u00f4ng v\u0169 v\u00e0 t\u1ed5ng h\u1ee3p protein, methionine lu\u00f4n \u0111\u01b0\u1ee3c xem l\u00e0 amino axit thi\u1ebft y\u1ebfu \u0111\u1ea7u ti\u00ean \u0111\u1ed1i v\u1edbi gia c\u1ea7m. \u1ea2nh: Jan Willem Schoulten<\/em><\/p>\n

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S\u1eed d\u1ee5ng methionine trong kh\u1ea9u ph\u1ea7n gia c\u1ea7m<\/strong><\/p>\n

V\u00ec l\u01b0\u1ee3ng methionine l\u00e0 gi\u1edbi h\u1ea1n trong ngu\u1ed3n protein th\u1ef1c v\u1eadt trong khi \u0111\u00f3 gia c\u1ea7m c\u00f3 nhu c\u1ea7u methionine cao \u0111\u1ec3 ph\u00e1t tri\u1ec3n l\u00f4ng v\u0169 v\u00e0 t\u1ed5ng h\u1ee3p protein, methionine lu\u00f4n \u0111\u01b0\u1ee3c xem l\u00e0 amino axit thi\u1ebft y\u1ebfu \u0111\u1ea7u ti\u00ean \u0111\u1ed1i v\u1edbi gia c\u1ea7m. Methionine c\u00f3 nhi\u1ec1u ch\u1ee9c n\u0103ng sinh l\u00fd v\u00ed d\u1ee5 n\u00f3 l\u00e0 ngu\u1ed3n cung c\u1ea5p methyl quan tr\u1ecdng cho c\u00e1c nh\u00f3m methyl (CH4) c\u1ea7n thi\u1ebft cho s\u1ef1 trao \u0111\u1ed5i ch\u1ea5t trong c\u01a1 th\u1ec3. Methionine c\u0169ng c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m stress oxy ho\u00e1 trong c\u01a1 th\u1ec3 b\u1eb1ng c\u00e1ch t\u0103ng c\u00e1c h\u1ee3p ch\u1ea5t ch\u1ed1ng oxy ho\u00e1 nh\u01b0 glutathione.<\/p>\n

C\u00e1c ch\u1ea5t s\u1ea3n ph\u1ea9m methionine d\u00f9ng cho gia c\u1ea7m v\u00e0 c\u00e1c lo\u00e0i kh\u00e1c nh\u01b0 l\u00e0 L-methionine, DL-methionine ho\u1eb7c MHA-FA c\u00f3 g\u1ed1c hydroxyl t\u01b0\u01a1ng t\u1ef1 methionine. T\u1ea5t c\u1ea3 c\u00e1c th\u1ef1c v\u1eadt v\u00e0 \u0111\u1ed9ng v\u1eadt ch\u1ec9 c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng methionine \u0111\u1ed3ng ph\u00e2n L v\u00e0 ch\u1ec9 methionine lo\u1ea1i L c\u00f3 trong protein. \u0110\u1ed3ng ph\u00e2n D c\u1ee7a methionine v\u00e0 d\u1ea1ng kh\u00e1c c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng, nh\u01b0ng n\u00f3 ph\u1ea3i \u0111\u01b0\u1ee3c chuy\u1ec3n \u0111\u1ed5i th\u00e0nh d\u1ea1ng L th\u00f4ng qua ph\u1ea3n \u1ee9ng enzyme trong c\u01a1 th\u1ec3 (H\u00ecnh 1). Tuy nhi\u00ean, c\u00e2u h\u1ecfi \u0111\u1eb7t ra l\u00e0 li\u1ec7u nh\u00f3m amino axit b\u1ecb ph\u00e2n t\u00e1ch c\u00f3 th\u1ec3 tr\u1edf v\u1ec1 d\u1ea1ng khung h\u00f3a h\u1ecdc methionine v\u1edbi hi\u1ec7u su\u1ea5t 100% hay kh\u00f4ng. Ngo\u00e0i ra, 2 ph\u1ea3n \u1ee9ng enzyme trong qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i \u0111\u1ed3ng ph\u00e2n c\u1ea7n c\u00f3 n\u0103ng l\u01b0\u1ee3ng. V\u00ec v\u1eady, khi DL methionine ho\u1eb7c d\u1ea1ng kh\u00e1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng thay cho L-methionine, t\u00ednh sinh kh\u1ea3 d\u1ee5ng t\u01b0\u01a1ng \u0111\u1ed1i (RBA) t\u1ef1 nhi\u00ean gi\u1ea3m do ph\u1ea3i ti\u00eau th\u1ee5 th\u00eam n\u0103ng l\u01b0\u1ee3ng kh\u00f4ng c\u1ea7n thi\u1ebft cho vi\u1ec7c chuy\u1ec3n \u0111\u1ed5i enzyme.<\/p>\n

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H\u00ecnh 1 \u2013 Qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i t\u1eeb D-methionine sang L-methionine.<\/em><\/strong><\/p>\n

\"\"<\/p>\n

S\u1ef1 chuy\u1ec3n \u0111\u1ed5i D-methionine sang L-methionine<\/strong><\/p>\n

C\u00e1c enzyme DAAO (D-Amino acid oxidase) c\u1ea7n thi\u1ebft cho vi\u1ec7c chuy\u1ec3n \u0111\u1ed5i D-methionine c\u00f3 r\u1ea5t nhi\u1ec1u trong gan v\u00e0 th\u1eadn c\u1ee7a g\u00e0 con. Tuy nhi\u00ean, theo D Aniello (1993), l\u01b0\u1ee3ng enzyme trong c\u01a1 th\u1ec3 g\u00e0 con th\u1ea5p h\u01a1n. Khi con v\u1eadt ph\u00e1t tri\u1ec3n, ho\u1ea1t \u0111\u1ed9ng c\u1ee7a enzyme t\u0103ng l\u00ean, nh\u01b0ng ph\u1ea3i m\u1ea5t m\u1ed9t th\u1eddi gian \u0111\u00e1ng k\u1ec3 \u0111\u1ec3 k\u00edch ho\u1ea1t \u0111\u1ee7 l\u01b0\u1ee3ng trong c\u01a1 th\u1ec3, nh\u01b0 minh h\u1ecda trong h\u00ecnh 2.<\/p>\n

Ng\u01b0\u1eddi ta bi\u1ebft r\u1eb1ng hi\u1ec7u qu\u1ea3 t\u0103ng tr\u01b0\u1edfng c\u1ee7a g\u00e0 th\u1ecbt trong tu\u1ea7n \u0111\u1ea7u ti\u00ean c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u1edbn \u0111\u1ebfn hi\u1ec7u qu\u1ea3 t\u1ed5ng th\u1ec3. Tr\u1ecdng l\u01b0\u1ee3ng l\u00fac m\u1edbi n\u1edf c\u1ee7a g\u00e0 con ch\u1ec9 l\u00e0 40g v\u00e0 ch\u00fang ph\u1ea3i t\u0103ng tr\u1ecdng l\u01b0\u1ee3ng l\u00ean 4,5 l\u1ea7n (180g) sau 1 tu\u1ea7n \u0111\u1ec3 duy tr\u00ec th\u1ec3 tr\u1ecdng ti\u00eau chu\u1ea9n v\u00e0o ng\u00e0y xu\u1ea5t chu\u1ed3ng \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u1ecbnh tr\u01b0\u1edbc. N\u1ebfu tr\u1ecdng l\u01b0\u1ee3ng g\u00e0 trong tu\u1ea7n \u0111\u1ea7u th\u1ea5p h\u01a1n 10g th\u00ec tr\u1ecdng l\u01b0\u1ee3ng xu\u1ea5t chu\u1ed3ng c\u00f3 th\u1ec3 gi\u1ea3m xu\u1ed1ng 60-70g v\u00e0o th\u1eddi \u0111i\u1ec3m b\u00e1n th\u1ecbt \u1edf 35 ng\u00e0y tu\u1ed5i. V\u00ec v\u1eady, vi\u1ec7c s\u1eed d\u1ee5ng D-methionine n\u00ean \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc \u0111\u1ec3 t\u1ed1i \u0111a h\u00f3a s\u1ef1 t\u0103ng tr\u01b0\u1edfng trong giai \u0111o\u1ea1n kh\u1edfi \u0111\u1ed9ng do D-methionine kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ho\u00e0n to\u00e0n \u1edf g\u00e0 con.<\/p>\n

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H\u00ecnh 2 \u2013 S\u1ef1 thay \u0111\u1ed5i ho\u1ea1t \u0111\u1ed9ng c\u1ee7a D- Amino acid oxidase trong \u0111\u1ed9ng v\u1eadt (D`Aniello, 1993).<\/em><\/strong><\/p>\n

\"\"<\/p>\n

\u1ea2nh h\u01b0\u1edfng c\u1ee7a methionine \u0111\u1ebfn \u0111\u01b0\u1eddng ru\u1ed9t<\/strong><\/p>\n

Glutathione \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong h\u00e0ng ph\u00f2ng v\u1ec7 ch\u1ed1ng oxi h\u00f3a c\u1ee7a \u0111\u1ed9ng v\u1eadt. N\u00f3 c\u00f3 kh\u1ea3 n\u0103ng ng\u0103n ng\u1eeba s\u1ef1 ph\u00e1 h\u1ee7y th\u00e0nh ph\u1ea7n t\u1ebf b\u00e0o ru\u1ed9t do c\u00e1c t\u00e1c nh\u00e2n oxy h\u00f3a nh\u01b0 c\u00e1c g\u1ed1c t\u1ef1 do, c\u00e1c peroxit v\u00e0 c\u00e1c kim lo\u1ea1i n\u1eb7ng. \u0110\u1eb7c bi\u1ec7t, n\u1ed3ng \u0111\u1ed9 glutathione t\u0103ng l\u00ean s\u1ebd t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n nhung mao \u1edf ru\u1ed9t non.<\/p>\n

Shen v\u00e0 c\u1ed9ng s\u1ef1 (2014, 2015) \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng khi cho \u0103n L-methionine s\u1ebd l\u00e0m gia t\u0103ng s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a nhung mao \u1edf c\u1ea3 g\u00e0 th\u1ecbt v\u00e0 heo so v\u1edbi cho \u0103n DL-methionine \u1edf con non (H\u00ecnh 3). Ph\u00e2n t\u00edch m\u00f4 nhung mao c\u1ee7a c\u1ea3 hai nghi\u1ec7m th\u1ee9c s\u1eed d\u1ee5ng L ho\u1eb7c DL cho th\u1ea5y h\u00e0m l\u01b0\u1ee3ng glutathione cao h\u01a1n \u0111\u00e1ng k\u1ec3 trong nh\u00f3m b\u1ed5 sung L-methionine. Ngo\u00e0i ra, c\u1ea3 chi\u1ec1u d\u00e0i v\u00e0 chi\u1ec1u r\u1ed9ng c\u1ee7a nhung mao \u0111\u1ec1u \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n trong nh\u00f3m b\u1ed5 sung L-methionine.<\/p>\n

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H\u00ecnh 3 \u2013 S\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 t\u1ed5ng h\u1ee3p glutathione v\u00e0 RBA gi\u1eefa L-methionine v\u00e0 DL-methionine (Shen v\u00e0 c\u1ed9ng s\u1ef1, n\u0103m 2015).<\/em><\/strong><\/p>\n

\"\"<\/p>\n

T\u1ea7m quan tr\u1ecdng c\u1ee7a methionine<\/strong><\/p>\n

Trong kh\u1ea9u ph\u1ea7n c\u1ee7a gia c\u1ea7m, methionine th\u01b0\u1eddng l\u00e0 amino axit thi\u1ebft y\u1ebfu \u0111\u1ea7u ti\u00ean. Methionine kh\u00f4ng ch\u1ec9 \u0111\u00f3ng vai tr\u00f2 nh\u01b0 m\u1ed9t th\u00e0nh ph\u1ea7n c\u1ee7a protein c\u01a1 th\u1ec3 m\u00e0 c\u00f2n li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a h\u1ec7 ti\u00eau h\u00f3a v\u00e0 hi\u1ec7u qu\u1ea3 t\u0103ng tr\u01b0\u1edfng. H\u01a1n n\u1eefa, n\u00f3 c\u00f2n c\u00f3 ch\u1ee9c n\u0103ng l\u00e0m t\u0103ng l\u01b0\u1ee3ng c\u01a1, c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ed9 l\u00f4ng v\u00e0 t\u1ef7 l\u1ec7 \u0111\u1ebb tr\u1ee9ng \u1edf gia c\u1ea7m.<\/p>\n

Vai tr\u00f2 v\u1ec1 ch\u1ee9c n\u0103ng sinh l\u00fd c\u1ee7a methionine n\u00ean \u0111\u01b0\u1ee3c l\u01b0u \u00fd. L-methionine l\u00e0 m\u1ed9t d\u1ea1ng methionine c\u00f3 t\u00ednh sinh kh\u1ea3 d\u1ee5ng sinh h\u1ecdc cao \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng d\u1ec5 d\u00e0ng b\u1edfi c\u00e1c t\u1ebf b\u00e0o ru\u1ed9t c\u1ee7a g\u00e0 con.<\/p>\n

 <\/p>\n

Theo AllAboutFeed<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Hi\u1ec3u bi\u1ebft v\u1ec1 l\u1ee3i \u00edch c\u1ee7a c\u00e1c axit amin \u0111\u00e3 c\u00f3 nhi\u1ec1u thay \u0111\u1ed5i trong th\u1eddi gian v\u1eeba qua v\u00ec ng\u00e0nh c\u00f4ng ngh\u1ec7 sinh h\u00f3a ti\u1ebfp t\u1ee5c ph\u00e1t tri\u1ec3n trong ch\u0103n nu\u00f4i \u0111\u1ed9ng v\u1eadt v\u00e0 dinh d\u01b0\u1ee1ng cho con ng\u01b0\u1eddi. … \u0110\u1ecdc th\u00eam<\/a><\/p>\n","protected":false},"author":722,"featured_media":7323,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27,89],"tags":[949,246,951,199,950,935,936,948,780,74,790,112,916,871,952,947,868,946,138,125,862,749,791],"class_list":["post-7322","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-industry-news","tag-chan-nuoi-ga-thit","tag-chan-nuoi-thu-y","tag-con-giong-ga-thit","tag-dinh-duong","tag-dinh-duong-cho-ga-thit","tag-dinh-duong-cho-gia-cam","tag-dinh-duong-gia-cam","tag-duoc-pham","tag-enzyme","tag-gia-cam","tag-khoang","tag-khoang-vi-luong","tag-luong-vitamin","tag-men-tieu-hoa","tag-methionine","tag-protein-dong-vat","tag-protein-tho","tag-protein-thuc-vat","tag-thu-y","tag-thuoc-thu-y","tag-thuoc-thu-y-apa","tag-veterinary","tag-vitamin"],"_links":{"self":[{"href":"https:\/\/apanano.vn\/vi\/wp-json\/wp\/v2\/posts\/7322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apanano.vn\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/apanano.vn\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/apanano.vn\/vi\/wp-json\/wp\/v2\/users\/722"}],"replies":[{"embeddable":true,"href":"https:\/\/apanano.vn\/vi\/wp-json\/wp\/v2\/comments?post=7322"}],"version-history":[{"count":1,"href":"https:\/\/apanano.vn\/vi\/wp-json\/wp\/v2\/posts\/7322\/revisions"}],"predecessor-version":[{"id":7324,"href":"https:\/\/apanano.vn\/vi\/wp-json\/wp\/v2\/posts\/7322\/revisions\/7324"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apanano.vn\/vi\/wp-json\/wp\/v2\/media\/7323"}],"wp:attachment":[{"href":"https:\/\/apanano.vn\/vi\/wp-json\/wp\/v2\/media?parent=7322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apanano.vn\/vi\/wp-json\/wp\/v2\/categories?post=7322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/apanano.vn\/vi\/wp-json\/wp\/v2\/tags?post=7322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}