{"id":7260,"date":"2024-01-09T09:06:03","date_gmt":"2024-01-09T02:06:03","guid":{"rendered":"https:\/\/apanano.com\/vi\/?p=7260"},"modified":"2024-01-09T09:06:03","modified_gmt":"2024-01-09T02:06:03","slug":"3-loi-ich-cua-xo-khong-tan-doi-voi-heo-cai-sua","status":"publish","type":"post","link":"https:\/\/apanano.vn\/en\/news\/3-loi-ich-cua-xo-khong-tan-doi-voi-heo-cai-sua\/","title":{"rendered":"3 l\u1ee3i \u00edch c\u1ee7a x\u01a1 kh\u00f4ng tan \u0111\u1ed1i v\u1edbi heo cai s\u1eefa"},"content":{"rendered":"

C\u00e1c x\u01a1 kh\u00f4ng tan trong kh\u1ea9u ph\u1ea7n c\u00f3 th\u1ec3 c\u00f3 l\u1ee3i cho s\u1ee9c kh\u1ecfe \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 gi\u1ea3m t\u1ef7 l\u1ec7 ti\u00eau ch\u1ea3y tr\u00ean heo. \u1ea2nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 c\u1ee7a x\u01a1 kh\u00f4ng tan \u0111\u1ebfn t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh ti\u00eau ch\u1ea3y \u0111\u00e3 \u0111\u01b0\u1ee3c nh\u1eadn th\u1ea5y \u1edf heo \u0103n kh\u1ea9u ph\u1ea7n c\u00f3 nhi\u1ec1u x\u01a1 kh\u00f4ng tan so v\u1edbi kh\u1ea9u ph\u1ea7n \u0111\u1ed1i ch\u1ee9ng.\u00a0<\/strong><\/p>\n

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Gi\u1edbi thi\u1ec7u<\/strong><\/p>\n

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Cai s\u1eefa l\u00e0 m\u1ed9t trong nh\u1eefng giai \u0111o\u1ea1n c\u0103ng th\u1eb3ng v\u00e0 kh\u00f3 kh\u0103n nh\u1ea5t trong cu\u1ed9c \u0111\u1eddi c\u1ee7a heo (1). Heo con m\u1edbi cai s\u1eefa th\u01b0\u1eddng b\u1ecb stress do c\u00e1c y\u1ebfu t\u1ed1 dinh d\u01b0\u1ee1ng, t\u00e2m l\u200e\u200e\u200e\u00fd, m\u00f4i tr\u01b0\u1eddng, sinh l\u200e\u00fd,\u2026 (2,3). Do c\u00e1c y\u1ebfu t\u1ed1 stress tr\u00ean, heo con th\u01b0\u1eddng c\u00f3 c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m l\u00e0 gi\u1ea3m n\u0103ng su\u1ea5t t\u0103ng tr\u01b0\u1edfng v\u00e0 gia t\u0103ng t\u1ef7 l\u1ec7 ti\u00eau ch\u1ea3y sau cai s\u1eefa (4,5). Khi tr\u1ea3i qua qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i t\u1eeb s\u1eefa m\u1eb9 sang th\u1ee9c \u0103n cai s\u1eefa, heo con b\u1ecb gi\u1ea3m l\u01b0\u1ee3ng \u0103n v\u00e0o m\u1ed9t c\u00e1ch nghi\u00eam tr\u1ecdng trong v\u00e0i ng\u00e0y \u0111\u1ea7u sau khi cai s\u1eefa (6). H\u01a1n n\u1eefa, \u0111\u1ec3 th\u00edch nghi v\u1edbi m\u00f4i tr\u01b0\u1eddng m\u1edbi, th\u00e0nh ph\u1ea7n h\u1ec7 vi sinh \u0111\u01b0\u1eddng ti\u00eau h\u00f3a c\u1ee7a heo con c\u0169ng b\u1ecb thay \u0111\u1ed5i do thay \u0111\u1ed5i c\u00e1ch \u0103n v\u00e0 th\u00e0nh ph\u1ea7n th\u1ee9c \u0103n (6). Giai \u0111o\u1ea1n n\u00e0y th\u01b0\u1eddng g\u1eafn li\u1ec1n v\u1edbi th\u00e1ch th\u1ee9c v\u1ec1 t\u0103ng tr\u01b0\u1edfng v\u00ec t\u1ef7 l\u1ec7 m\u1eafc c\u00e1c r\u1ed1i lo\u1ea1n \u0111\u01b0\u1eddng ti\u00eau h\u00f3a cao, ch\u1eb3ng h\u1ea1n nh\u01b0 Ti\u00eau ch\u1ea3y Sau Cai s\u1eefa (TCSCS) (7).<\/p>\n

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Ti\u00eau ch\u1ea3y sau cai s\u1eefa \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe quan tr\u1ecdng v\u00e0 c\u00f3 t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh v\u00e0 t\u1ef7 l\u1ec7 ch\u1ebft \u0111\u00e1ng k\u1ec3 (8,9). TCSCS \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 m\u1ed9t b\u1ec7nh ti\u00eau h\u00f3a \u0111a nguy\u00ean nh\u00e2n, v\u00e0 thi\u1ebfu dinh d\u01b0\u1ee1ng l\u00e0 m\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n ch\u00ednh (10-12). \u0110\u01b0\u1eddng ti\u00eau h\u00f3a l\u00e0 m\u1ed9t h\u1ec7 sinh th\u00e1i ph\u1ee9c t\u1ea1p v\u00e0 c\u00e2n b\u1eb1ng (4,13). Th\u00e0nh ph\u1ea7n kh\u1ea9u ph\u1ea7n l\u00e0 y\u1ebfu t\u1ed1 \u1ea3nh h\u01b0\u1edfng ch\u00ednh \u0111\u1ebfn h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t (14, 15). Do \u0111\u00f3, khi x\u00e9t \u0111\u1ebfn s\u1ef1 c\u00e2n b\u1eb1ng gi\u1eefa h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 th\u00e0nh ph\u1ea7n kh\u1ea9u ph\u1ea7n, th\u00ec TCSCS l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1 l\u1edbn trong su\u1ed1t giai \u0111o\u1ea1n sau cai s\u1eefa. (11,16).<\/p>\n

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C\u00e1ch hi\u1ec7u qu\u1ea3 nh\u1ea5t \u0111\u1ec3 gi\u1ea3m m\u1ee9c \u0111\u1ed9 TCSCS l\u00e0 \u0111i\u1ec1u ch\u1ec9nh th\u00e0nh ph\u1ea7n dinh d\u01b0\u1ee1ng kh\u1ea9u ph\u1ea7n (15,17). Nhi\u1ec1u bi\u1ec7n ph\u00e1p dinh d\u01b0\u1ee1ng kh\u00e1c nhau nh\u1eb1m c\u1ea3i thi\u1ec7n giai \u0111o\u1ea1n chuy\u1ec3n ti\u1ebfp cai s\u1eefa v\u00e0 gi\u1ea3m c\u00e1c b\u1ec7nh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong nhi\u1ec1u n\u0103m qua (11,18). B\u1eb1ng ch\u1ee9ng cho th\u1ea5y r\u1eb1ng c\u00e1c can thi\u1ec7p c\u1ee5 th\u1ec3 v\u1ec1 kh\u1ea9u ph\u1ea7n, nh\u01b0 ki\u1ec3m so\u00e1t protein (19,20), x\u01a1 (21), tinh b\u1ed9t (22), c\u00e2n b\u1eb1ng \u0111i\u1ec7n gi\u1ea3i (23) v\u00e0 c\u00e1c th\u00e0nh ph\u1ea7n kh\u00e1c trong kh\u1ea9u ph\u1ea7n \u0103n h\u00e0ng ng\u00e0y c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m s\u1ef1 gia t\u0103ng c\u1ee7a TCSCS (11,24,25). M\u1ee5c \u0111\u00edch c\u1ee7a b\u00e0i t\u1ed5ng quan n\u00e0y l\u00e0 t\u00f3m t\u1eaft m\u1ed9t s\u1ed1 lo\u1ea1i TCSCS ph\u1ed5 bi\u1ebfn \u0111\u1ec3 l\u00e0m r\u00f5 h\u01a1n vai tr\u00f2 c\u1ee7a dinh d\u01b0\u1ee1ng trong vi\u1ec7c g\u00e2y ra v\u00e0 ki\u1ec3m so\u00e1t TCSCS.<\/p>\n

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C\u00e1c carbohydrate c\u00f3 th\u1ec3 l\u00ean men l\u00e0 ngu\u1ed3n n\u0103ng l\u01b0\u1ee3ng ch\u00ednh cho qu\u00e1 tr\u00ecnh l\u00ean men c\u1ee7a vi sinh v\u1eadt v\u00e0 do \u0111\u00f3 c\u00f3 th\u1ec3 ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t s\u1ef1 li\u00ean k\u1ebft gi\u1eefa heo con v\u00e0 h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t c\u1ee7a n\u00f3 (59, 60). H\u01a1n n\u1eefa, c\u00e1c x\u01a1 kh\u00f4ng tan trong kh\u1ea9u ph\u1ea7n c\u00f3 th\u1ec3 c\u00f3 l\u1ee3i cho s\u1ee9c kh\u1ecfe \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 gi\u1ea3m t\u1ef7 l\u1ec7 ti\u00eau ch\u1ea3y tr\u00ean heo (61,62). \u1ea2nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 c\u1ee7a x\u01a1 kh\u00f4ng tan \u0111\u1ebfn t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh ti\u00eau ch\u1ea3y \u0111\u00e3 \u0111\u01b0\u1ee3c nh\u1eadn th\u1ea5y \u1edf heo \u0103n kh\u1ea9u ph\u1ea7n c\u00f3 nhi\u1ec1u x\u01a1 kh\u00f4ng tan so v\u1edbi kh\u1ea9u ph\u1ea7n \u0111\u1ed1i ch\u1ee9ng (63,63). S\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 t\u1ef7 l\u1ec7 ti\u00eau ch\u1ea3y \u0111\u00e3 \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea7y gi\u1eefa c\u00e1c ngu\u1ed3n x\u01a1 kh\u00e1c nhau (60).<\/p>\n

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1.\u00a0\u1ea2nh h\u01b0\u1edfng c\u1ee7a x\u01a1 kh\u00f4ng tan \u0111\u1ebfn hi\u1ec7u su\u1ea5t t\u0103ng tr\u01b0\u1edfng v\u00e0 t\u1ef7 l\u1ec7 ti\u00eau h\u00f3a c\u00e1c ch\u1ea5t dinh d\u01b0\u1ee1ng c\u1ee7a heo con cai s\u1eefa\u00a0<\/strong><\/p>\n

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B\u1ed5 sung x\u01a1 kh\u00f4ng tan trong kh\u1ea9u ph\u1ea7n h\u00e0ng ng\u00e0y c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n s\u1ef1 th\u00edch nghi c\u1ee7a heo con trong su\u1ed1t qu\u00e1 tr\u00ecnh cai s\u1eefa (64). T\u00f9y v\u00e0o lo\u1ea1i x\u01a1 m\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a vi\u1ec7c cho \u0103n kh\u1ea9u ph\u1ea7n x\u01a1 cao \u0111\u1ed1i v\u1edbi n\u0103ng su\u1ea5t c\u1ee7a heo con s\u1ebd kh\u00e1c nhau (62,63). T\u00e1c \u0111\u1ed9ng c\u1ee7a x\u01a1 kh\u00f4ng tan \u0111\u1ebfn dinh d\u01b0\u1ee1ng c\u1ee7a heo con c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1eb1ng c\u00e1c \u0111\u1eb7c t\u00ednh v\u00e0 ngu\u1ed3n c\u1ee7a ch\u1ea5t x\u01a1 (65, 66). V\u00ed d\u1ee5, ch\u1ea5t x\u01a1 trong c\u00e1m l\u00faa m\u00ec \u0111\u01b0\u1ee3c heo con ch\u1ea5p nh\u1eadn v\u00e0 ho\u1ea1t \u0111\u1ed9ng nh\u01b0 c\u00e1c prebiotic (60). C\u00e1m l\u00faa m\u00ec l\u00e0 m\u1ed9t lo\u1ea1i x\u01a1 kh\u00f4ng tan v\u00e0 khi \u0111\u01b0\u1ee3c b\u1ed5 sung v\u00e0o kh\u1ea9u ph\u1ea7n heo cai s\u1eefa, c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn t\u0103ng l\u01b0\u1ee3ng \u0103n v\u00e0o v\u00e0 t\u0103ng s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a \u0111\u01b0\u1eddng ti\u00eau h\u00f3a (67,68). Tuy nhi\u00ean c\u1ea7n th\u00eam nhi\u1ec1u nghi\u00ean c\u1ee9u h\u01a1n \u0111\u1ec3 l\u00e0m r\u00f5 \u1ea3nh h\u01b0\u1edfng c\u1ee7a x\u01a1 kh\u00f4ng tan trong kh\u1ea9u ph\u1ea7n \u0111\u1ebfn n\u0103ng su\u1ea5t t\u0103ng tr\u01b0\u1edfng c\u1ee7a heo cai s\u1eefa.<\/p>\n

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2.\u00a0\u1ea2nh h\u01b0\u1edfng c\u1ee7a x\u01a1 kh\u00f4ng tan \u0111\u1ebfn s\u1ee9c kh\u1ecfe \u0111\u1eebng ru\u1ed9t c\u1ee7a heo cai s\u1eefa\u00a0<\/strong><\/p>\n

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X\u00e9t v\u1ec1 vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t, x\u01a1 kh\u1ea9u ph\u1ea7n c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ee9c kh\u1ecfe c\u1ee7a heo trong th\u1eddi gian cai s\u1eefa (69,70). C\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y cho th\u1ea5y t\u1ef7 l\u1ec7 chi\u1ec1u cao nhung mao : \u0111\u1ed9 s\u00e2u g\u1ed1c nhung mao th\u1ea5p h\u01a1n c\u00f3 li\u00ean quan \u0111\u1ebfn c\u00e1c th\u00e1ch th\u1ee9c v\u1ec1 vi sinh v\u1eadt v\u00e0 c\u00e1c th\u00e0nh ph\u1ea7n kh\u00e1ng nguy\u00ean trong th\u1ee9c \u0103n (71,72). H\u01a1n n\u1eefa, m\u1ed9t nghi\u00ean c\u1ee9u v\u1ec1 h\u00ecnh th\u00e1i ni\u00eam m\u1ea1c ru\u1ed9t \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t c\u1ee7a ru\u1ed9t \u0111\u1ea3m b\u1ea3o t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a ni\u00eam m\u1ea1c (73, 74). Th\u00eam x\u01a1 c\u00e1m l\u00faa m\u00ec v\u00e0o kh\u1ea9u ph\u1ea7n h\u1eb1ng ng\u00e0y gi\u00fap l\u00e0m t\u0103ng t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a ni\u00eam m\u1ea1c h\u1ed3i tr\u00e0ng b\u1eb1ng c\u00e1ch c\u1ea3i thi\u1ec7n chi\u1ec1u cao nhung mao v\u00e0 t\u0103ng t\u1ef7 l\u1ec7 chi\u1ec1u cao nhung mao : \u0111\u1ed9 s\u00e2u g\u1ed1c nhung mao, \u0111i\u1ec1u n\u00e0y ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y cho th\u1ea5y r\u1eb1ng cho \u0103n kh\u1ea9u ph\u1ea7n gi\u00e0u x\u01a1 kh\u00f4ng tan gi\u00fap b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i c\u00e1c vi khu\u1ea9n g\u00e2y b\u1ec7nh b\u1eb1ng c\u00e1ch t\u0103ng chi\u1ec1u d\u00e0i nhung mao (75,76). H\u01a1n n\u1eefa, nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng heo con \u0111\u01b0\u1ee3c \u0103n kh\u1ea9u ph\u1ea7n c\u00f3 ch\u1ee9a x\u01a1 kh\u00f4ng tan c\u00f3 nhi\u1ec1u t\u1ebf b\u00e0o ly \u1edf h\u1ed3i tr\u00e0ng h\u01a1n so v\u1edbi heo con \u0103n kh\u1ea9u ph\u1ea7n kh\u00f4ng c\u00f3 ch\u1ea5t x\u01a1 (77,78). C\u00e1c t\u1ebf b\u00e0o ly \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong ru\u1ed9t b\u1edfi ch\u00fang t\u1ed5ng h\u1ee3p v\u00e0 ti\u1ebft ra c\u00e1c ch\u1ea5t trung gian, ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong ru\u1ed9t non v\u00e0 ru\u1ed9t gi\u00e0, gi\u00fap ch\u1ed1ng l\u1ea1i s\u1ef1 ph\u00e2n gi\u1ea3i protein v\u00e0 k\u00edch th\u00edch qu\u00e1 tr\u00ecnh s\u1eeda ch\u1eefa, ch\u1eb3ng h\u1ea1n nh\u01b0 c\u00e1c y\u1ebfu t\u1ed1 Trefoil peptide v\u00e0 ch\u1ea5t nh\u1ea7y (24, 74). C\u00e1c nghi\u00ean c\u1ee9u cho r\u1eb1ng heo con \u0111\u01b0\u1ee3c \u0103n kh\u1ea9u ph\u1ea7n ch\u1ee9a nhi\u1ec1u ch\u1ea5t x\u01a1 kh\u00f4ng tan h\u01a1n s\u1ebd c\u00f3 n\u1ed3ng \u0111\u1ed9 TGF-\u03b1 trong k\u1ebft tr\u00e0ng cao h\u01a1n c\u00e1c kh\u1ea9u ph\u1ea7n \u0111\u1ed1i ch\u1ee9ng (80). Nh\u00ecn chung, kh\u1ea9u ph\u1ea7n x\u01a1 cao c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng h\u00e0ng r\u00e0o ru\u1ed9t b\u1eb1ng c\u00e1ch t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u00e1c y\u1ebfu t\u1ed1 li\u00ean quan \u0111\u1ebfn ch\u1ee9c n\u0103ng h\u00e0ng r\u00e0o ru\u1ed9t. Tuy nhi\u00ean, c\u00e1c lo\u1ea1i x\u01a1 kh\u00e1c nhau s\u1ebd t\u1ea1o ra nh\u1eefng thay \u0111\u1ed5i kh\u00e1c nhau trong vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t (81,82).<\/p>\n

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3.\u00a0Ch\u1ea5t\u00a0x\u01a1 kh\u00f4ng tan gi\u00fap gi\u1ea3m t\u1ef7 l\u1ec7 ti\u00eau ch\u1ea3y sau cai s\u1eefa<\/strong><\/p>\n

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X\u01a1 kh\u00f4ng tan trong kh\u1ea9u ph\u1ea7n \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 gi\u00fap c\u1ea3i thi\u1ec7n s\u1ee9c kh\u1ecfe \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 gi\u1ea3m t\u1ef7 l\u1ec7 ti\u00eau ch\u1ea3y tr\u00ean heo (61, 83). Kh\u1ea9u ph\u1ea7n b\u1ed5 sung c\u00e1m l\u00faa m\u00ec \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 gi\u00fap gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng vi khu\u1ea9n E.coli trong ph\u00e2n v\u00e0 gi\u1ea3m t\u1ef7 l\u1ec7 TCSCS (61,84). Kh\u1ea9u ph\u1ea7n \u0103n c\u00f3 x\u01a1 h\u1ea1t \u0111\u1eadu \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n s\u1ee9c kh\u1ecfe \u0111\u01b0\u1eddng ru\u1ed9t b\u1eb1ng c\u00e1ch gi\u1ea3m s\u1ef1 k\u1ebft b\u00e1m c\u1ee7a vi khu\u1ea9n v\u00e0 t\u0103ng b\u00e0i th\u1ea3i E.coli, v\u00e0 kh\u1ea9u ph\u1ea7n nh\u01b0 v\u1eady c\u0169ng c\u00f3 th\u1ec3 gi\u1ea3m t\u1ef7 l\u1ec7 TCSCS (85). C\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 t\u1ef7 l\u1ec7 TCSCS gi\u1eefa c\u00e1c kh\u1ea9u ph\u1ea7n c\u00f3 ngu\u1ed3n x\u01a1 kh\u00f4ng tan kh\u00e1c nhau (64, 86). C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng c\u1ee7a x\u01a1 kh\u00f4ng tan \u0111\u1ebfn \u0111\u1ebfn t\u1ef7 l\u1ec7 TCSCS c\u00f3 th\u1ec3 do ch\u1ee9c n\u0103ng \u0111i\u1ec1u h\u00f2a vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t (87). C\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng cho heo con cai s\u1eefa \u0103n kh\u1ea9u ph\u1ea7n gi\u00e0u ch\u1ea5t x\u01a1 kh\u00f4ng h\u00f2a tan c\u00f3 th\u1ec3 b\u1ea3o v\u1ec7 heo t\u1ed1t h\u01a1n trong vi\u1ec7c ch\u1ed1ng l\u1ea1i c\u00e1c vi khu\u1ea9n g\u00e2y b\u1ec7nh b\u1eb1ng c\u00e1ch t\u0103ng chi\u1ec1u d\u00e0i nhung mao (85,88). T\u00ednh to\u00e0n v\u1eb9n c\u1ee7a h\u00e0ng r\u00e0o bi\u1ec3u m\u00f4 ru\u1ed9t ph\u1ea3n \u00e1nh kh\u00f4ng gian n\u1ed9i b\u00e0o gi\u1eefa c\u00e1c t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 v\u00e0 c\u00f3 th\u1ec3 ng\u0103n c\u1ea3n s\u1ef1 khu\u1ebfch t\u00e1n c\u1ee7a c\u00e1c vi khu\u1ea9n qua l\u1edbp bi\u1ec3u m\u00f4 ru\u1ed9t (89). Ngo\u00e0i ra, c\u00e1c protein n\u1ed1i ch\u1eb7t \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a h\u00e0ng r\u00e0o ru\u1ed9t (90). L\u1ee3i khu\u1ea9n Lactobacillus c\u00f3 th\u1ec3 gi\u00fap t\u0103ng n\u1ed3ng \u0111\u1ed9 mRNA occludin c\u1ee7a t\u1ebf b\u00e0o Caco-2, trong khi E.coli l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 ph\u1ee9c h\u1ee3p m\u1ed1i n\u1ed1i ch\u1eb7t ZO-1, occludin v\u00e0 claudin-1 trong c\u00e1c t\u1ebft b\u00e0o bi\u1ec3u m\u00f4 ru\u1ed9t, \u0111i\u1ec1u n\u00e0y ch\u1ee9ng minh r\u1eb1ng vi khu\u1ea9n c\u00f3 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a h\u00e0ng r\u00e0o ru\u1ed9t b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh m\u1ee9c \u0111\u1ed9 bi\u1ec3u hi\u1ec7n gen c\u1ee7a c\u00e1c protein n\u1ed1i ch\u1eb7t (91,92). \u1ea2nh h\u01b0\u1edfng c\u1ee7a x\u01a1 kh\u00f4ng tan \u0111\u1ebfn c\u00e1c protein n\u1ed1i ch\u1eb7t c\u00f3 li\u00ean quan \u0111\u1ebfn s\u1ed1 l\u01b0\u1ee3ng c\u00e1c l\u1ee3i khu\u1ea9n bifidobacteria v\u00e0 lactobacili (93). X\u01a1 kh\u00f4ng tan trong kh\u1ea9u ph\u1ea7n c\u0169ng th\u00fac \u0111\u1ea9y n\u1ed3ng \u0111\u1ed9 mRNA c\u1ee7a c\u00e1c cytokine ti\u1ec1n vi\u00eam (IL-1 v\u00e0 TNF-\u03b1) nh\u01b0 l\u00e0 c\u00e1c y\u1ebfu t\u1ed1 can thi\u1ec7p c\u1ee7a h\u00e0ng r\u00e0o ru\u1ed9t (94,95). Tuy nhi\u00ean, c\u1ea7n c\u00f3 c\u00e1c nghi\u00ean c\u1ee9u th\u00eam v\u1ec1 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa TCSCS v\u00e0 s\u1ef1 thay \u0111\u1ed5i vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t qua trung gian l\u00e0 ch\u1ea5t x\u01a1 kh\u00f4ng tan trong kh\u1ea9u ph\u1ea7n.<\/p>\n

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X\u01a1 kh\u00f4ng tan c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ee9c n\u0103ng h\u00e0ng r\u00e0o ni\u00eam m\u1ea1c ru\u1ed9t v\u00e0 \u0111i\u1ec1u ch\u1ec9nh vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t \u1edf heo con cai s\u1eefa. Ngo\u00e0i ra, x\u01a1 kh\u00f4ng tan c\u0169ng \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 quan tr\u1ecdng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ee9c n\u0103ng h\u00e0ng r\u00e0o ru\u1ed9t c\u1ee7a heo con v\u00e0 c\u00f3 th\u1ec3 gi\u1ea3m t\u1ef7 l\u1ec7 TCSCS (h\u00ecnh 1).<\/p>\n

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TGF-\u03b1: Y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng chuy\u1ec3n \u03b1<\/p>\n

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Ngu\u1ed3n:\u00a0Biomed Research International<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

C\u00e1c x\u01a1 kh\u00f4ng tan trong kh\u1ea9u ph\u1ea7n c\u00f3 th\u1ec3 c\u00f3 l\u1ee3i cho s\u1ee9c kh\u1ecfe \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 gi\u1ea3m t\u1ef7 l\u1ec7 ti\u00eau ch\u1ea3y tr\u00ean heo. \u1ea2nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 c\u1ee7a x\u01a1 kh\u00f4ng tan \u0111\u1ebfn t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh ti\u00eau ch\u1ea3y \u0111\u00e3 … Read More<\/a><\/p>\n","protected":false},"author":722,"featured_media":7261,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27,88],"tags":[820,932,72,246,199,917,845,780,821,163,828,790,112,916,871,933,868,918,138,905,934,125,862,832,749,791],"class_list":["post-7260","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-apa-news","tag-axit-beo","tag-axit-tannic","tag-chan-nuoi","tag-chan-nuoi-thu-y","tag-dinh-duong","tag-dinh-duong-cho-heo","tag-dinh-duong-cho-heo-con","tag-enzyme","tag-fcr","tag-gia-suc","tag-heo-cai-sua","tag-khoang","tag-khoang-vi-luong","tag-luong-vitamin","tag-men-tieu-hoa","tag-ngan-ngua-tieu-chay-sau-cai-sua","tag-protein-tho","tag-suc-khoe-cua-lon","tag-thu-y","tag-thuc-an-cho-lon","tag-thuc-an-cua-heo-cai-sua","tag-thuoc-thu-y","tag-thuoc-thu-y-apa","tag-tieu-hoa","tag-veterinary","tag-vitamin"],"_links":{"self":[{"href":"https:\/\/apanano.vn\/en\/wp-json\/wp\/v2\/posts\/7260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apanano.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/apanano.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/apanano.vn\/en\/wp-json\/wp\/v2\/users\/722"}],"replies":[{"embeddable":true,"href":"https:\/\/apanano.vn\/en\/wp-json\/wp\/v2\/comments?post=7260"}],"version-history":[{"count":1,"href":"https:\/\/apanano.vn\/en\/wp-json\/wp\/v2\/posts\/7260\/revisions"}],"predecessor-version":[{"id":7262,"href":"https:\/\/apanano.vn\/en\/wp-json\/wp\/v2\/posts\/7260\/revisions\/7262"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apanano.vn\/en\/wp-json\/wp\/v2\/media\/7261"}],"wp:attachment":[{"href":"https:\/\/apanano.vn\/en\/wp-json\/wp\/v2\/media?parent=7260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apanano.vn\/en\/wp-json\/wp\/v2\/categories?post=7260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/apanano.vn\/en\/wp-json\/wp\/v2\/tags?post=7260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}